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This is most relevant when vitamin B12 deficiency is being corrected and broader B-vitamin support is clinically appropriate, where symptoms include a combination of fatigue, neurological features, and stress, or where rapid repletion and functional support are desired

Univariable analysis was performed using the Students t test or the Wilcoxon rank-sum test, as appropriate, to compare continuous variables between the CUD and control groups, whereas Pearsons chi-square test or Fishers exact test was used for dichotomous and categorical variables, as appropriate

Li S, Ji X, Chao C, Liu Z, Zhu J, Peng H